Safety of Systemic Acridine Orange Administration with Low-dose Radiation in Mice
نویسندگان
چکیده
Acridine orange (AO) is a known radiation sensitizer, and concomitant local administration of AO and irradiation (5 Gy) after cytoreductive surgery results in good local control of musculoskeletal sarcomas in humans. Local administration of AO solution into the surgical field can act directly on residual tumor cells, and it is thought that systemic administration of AO may affect tumor cells invading neighboring tissues. However, the toxicity of AO and concomitant X-ray irradiation is not well described. The purpose of the present study was to evaluate the safety of intravenous (IV) administration of AO (1 mg/kg) and simultaneous radiotherapy in
منابع مشابه
Determination of the LD50 of acridine orange via intravenous administration in mice in preparation for clinical application to cancer therapy.
AIM We undertook studies to determine the lethal dose 50 (LD50) of acridine orange (AO) using mice in order to confirm the safety of intravenous administration of AO. MATERIALS AND METHODS We used 40 mice and AO was administered once intravenously. General behavior and mortality were continuously observed for 14 days. At the end of the experiment, all animals were sacrificed for subsequent st...
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